home azienda prodotti anatomia contatti
More info  

.: Riboflavin

Riboflavin (vitamin B2) is an heterocyclic compound obtained from a molecule of iso-allosazine to which it is bound to a ribitole chain.

Riboflavin is yellow in colour, scarcely soluble in water, remains stable under heat and becomes fluorescent under ultraviolet light.  When exposed to light, the photolysis reaction causes the detachment of the ribitole root and subsequent loss of the vitamin activity.

Riboflavin was first isolated in 1927 by Paul Gyorgy and in 1935 a synthesis was produced by Richard Kuhn. It can be found in many natural foods: beer yeast, offal, milk, albumen, fish, meat, green vegetables and is involved in many metabolic reactions, specially in human tissue.

lutein omega 3
Riboflavina base 0,100 g
Destrano T500 20 g
Sodio fosfato monobasico biidrato  
Sodio fosfato bibasico biidrato  
Cloruro di sodio  
Acqua depurata q.b. a 100 g

RICROLIN® - Ophthalmic solution for parasurgical use

RICROLIN® is an ophthalmic solution containing Riboflavin 0.1% instilled in the eye during irradiation of UV-A light as part of the parsurgical procedure of corneal collagen cross-linking. The principal objective of RICROLIN® is to provide a barrier against UV-A penetration beneath the corneal stroma, and thus protect the delicate internal structures of the eye (corneal endothelium, lens and retina) from damage that may be caused by radiation. RICROLIN solution is in fact capable of reducing up to 95% of the UV energy that reaches the deep strata of the cornea.

Product use

In association with ophthalmic UV-A radiation, the solution is administered during conservative parasurgical procedures for keratoconus and other corneal extasia pathologies The administration of RICROLINŽ in association with UV-A light retards the progression of Keratoconus. This treatment can prevent the necessity of corneal transplant.

5-10 minutes prior to irradiation, instil 1 or 2 drops of the solution using the appropriate dispenser provided During treatment with UV-A light instil the solution every 5 minutes, for a total of 30 minutes

RICROLIN® ophthalmic solution has no contraindications. Use must be avoided in cases of hypersensitivity reactions to the components of the product or to other chemically related substances.

No systemic side effects regarding the ocular surface have been reported.

- The product must be kept away from direct light
- Right up to the moment the product is to be utilised, it must be stored under refrigeration at a temperature between  +4 and +8°C
- Kept within its dispenser, the solution is maintained sterile
- Do not touch the eye surface or other objects with the cannula needle in order to avoid the risk of contamination to the solution
- The product must not be utilised after more than one hour from first use
- The dispenser must not be utilised for more than one patient
- The product must not be utilised after the date indicated on the package
- The product must not be kept at a temperature higher than 25°C
- The product is strictly indicated for external ophthalmic parasurgical use and is therefore utilised exclusively by registered Ophthalomologists
- The product must not be utilised if packaging is damaged

1 sterile single-use dispenser filled with 1ml solution
1 sterile single-use cannula needle

flaguk end