KRONEK® based on Forskolin, Rutin, Vitamins B1 and B2
- New frontier in glaucoma -
Glaucoma damage is defined as loss of the nerve cells of the retina and their fibres (which constitute the optic nerve) with subsequent defects in the visual field. In the beginning, these defects are not noted by the patient: this is why glaucoma is described as the silent thief of sight.
Today it is common opinion that it is not enough to have eye pressure under control: even in patients undergoing hypotonic treatment, glaucoma progresses and the “thief of sight” continues to cause deterioration of the visual field.
Risk factors for the development of glaucoma, as well as eye pressure, are, as is known, age, race, genetic predisposition, sex and immune defects.
Nevertheless progressive loss of the field of vision is mainly associated, by epidemiological studies, with:
• Circadian pressure fluctuations: it has been demonstrated that patients with great fluctuations in IOP have greater likelihood of suffering damage with progressive functional loss.
• Perfusion of the choroid and optic disc:
These two main risk factors cause the process called apoptosis or programmed cell death in ganglia and nerve cells.
Apoptosis is probably brought on by a reduced axonal flow of information (mechanical theory of compression) and circulatory problems (vascular theory). In this latter case, reperfusion, following a phase of reduced perfusion, leads to the formation of free radicals which also cause an increase in glutamate to toxic levels.
KRONEK® is a dietary supplement based on Coleus forskohlii root extract, Rutin, Vitamin B1 and Vitamin B2. The characteristic ingredient of the root extract of this plant is forskolin, a diterpenoid, the effects of which have all emerged from tests carried out.
The action mechanism of forskolin is mainly ascribed to the property which this plant has of activating an important enzyme, adenyl-cyclase, which leads to an increase on a cellular level of cyclic adenosinmonophosphate (cAMP) and all the functions in which it mediates.
Since cAMP is diminished in numerous disorders, its increase due to forskolin is held to be beneficial in these circumstances.
Adenyl-cyclase has an effect on the control of the production of aqueous humour.
Rutin helps to maintain or repair the physiological functioning of small blood vessels, whilst vitamins B1 and B2, as coenzymes, can help to maintain tissue trophism and, in terms of the nervous system, maintain neurosensorial eye function .
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