.: Specialized Tear Integration for dry eye syndrome in diabetics

There is no doubt that the majority of ophthalmologists and patients indissolubly link diabetes with retinal complications, that is with diabetic retinopathy.
It is known however, that diabetes results in other serious problems of the eye and, taking international literature into consideration, problems of the eye surface linked to this pathology increasingly call for the attention of researchers.
In particular, the biggest worry seems to be the level of damage to the corneal epithelium which can occur during the course of this disease.
This damage to the corneal epithelium seems to relate to a state of general decay of the nervous system linked to hyperglycemia, which, in some cases also involves the sensitive corneal nerve endings (diabetic neuropathy).
The sensitive corneal nerve endings respond to trophic needs and the moisture of the corneal tissue, sending messages to the lachrymal gland and the muciparous cells.
Alteration of this communication system results in lachrymal hyposecretion of increasing intensity, the seriousness of which may not be perceived by the patient, simply because they are affected by diabetic neurodystrophy of the cornea. This can result in serious alteration of this tissue which can manifest itself in what is known internationally as diabetic keratopathy.
When diagnosing this problem in a diabetic, is one faced with simple lachrymal hyposecretion or is it something more?
It is certainly something more, and therefore requires specific treatment with a product which responds adequately to lachrymal hyposecretion with very particular characteristics.
Careful studies on the therapeutic aspects of this disease have led to the development of TIORETIN® eyedrops which is a preparation based on lipoic acid, a molecule with very interesting characteristics.
Indeed, lipoic acid is a powerful antioxidant, participating in the regeneration of antioxidant enzyme complexes of fundamental importance in various tissues, as well as essential vitamins such as vitamins E and C, encouraging cell metabolism (it is an integral part of pyruvate dehydrogenase).
Lipoic acid also has a particular characteristic: it is a small molecule which easily reaches the anatomical areas where it carries out its important biological action.
Thanks to lipoic acid, TIORETIN® eyedrops have the following effects: epithelioprotective, trophic, neuroprotective and neurotrophic.
The aim of TIORETIN® eyedrops is to prevent degeneration of the corneal epithelium, maintain the efficiency of the sensitive corneal nerve endings and maintain adequate production of the lachrymal film.
In TIORETIN® eyedrops, lipoic acid has been associated with hypromellose, a substance with a lubricant and stablizing effect on the lachrymal film as well as having marked mucomimetic qualities, an ideal combination to achieve pre-established objectives: to help the diabetic patient to reduce discomfort tied to alterations in the lachrymal film and avoid the progression of the problem into more serious diseases.
TIORETIN® eyedrops also contain an innovative preservative complex based on N-IG + EDTA. This preservative complex (bactericide and antimicotic) has been shown to be very safe to use in the eye, in so far as it is non-sensitizing, non-irritant and non-epitheliotoxic. TIORETIN® eyedrops are the first eyedrops to be specifically developed for diabetics. The recommended dose is one drop into the conjunctival sac, 3 times a day or more, according to doctor’s instructions.

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